Preliminary googling looks like it helps boost serotonin. 100-200mg for anti-fatigue, 300-600mg for anti-stress, anti-anxiety. Unlike Kratom, Agmatine is an amino acid compound, which is also produced by our bodies. Press question mark to learn the rest of the keyboard shortcuts. https://www.reddit.com/r/Nootropics/comments/7ezn7q/substances_that_share_the_same_moa_as_ketamine/. You can start with a simple piracetam/alpha-gpc stack. This thread is archived. I’ve read it’s also a supplement for weight training. Moderate dosages, though slightly less potent that depression drugs such as Tofranil (imipramine), show a promising ability to improve mood and reduce anxiety. Sort by. But being on only 150 mg of Wellbutrin was really not doing my brain very well at all - brain fog, headaches, not wanting to get out of bed. That said, little research has been done on what the appropriate dosage should be. I use bulk agmatine and citruline malate by AI Sports, because then I can actually get 6-8g of citruline malate and 1g of Agmatine that way. I buy my noot powders from NootropicsDepot. Research has found agmatine to be non-toxic when taken appropriately. Here's the downside, HAIR-LOSS. In the brain Agmatine does not directly convert into Nitric Oxide like L Arginine does. Low quality posts will be removed. 76% Upvoted. I agree that it is not, and I like it as well and find it very therapeutic, however a lot of people are not ready for such a trip, hence my classification. I was upped to the 300mg Bupropin XL (of dubious bioequivalence) and after experiencing withdrawal symptoms, determined that serotonin reuptake may not be the issue at hand. What Is Agmatine? Try that for a few days. Agmatine Sulfate also provides a number of athletic benefits. The site may not work properly if you don't, If you do not update your browser, we suggest you visit, Press J to jump to the feed. Contrary to popular belief, Agmatine is not as … It was noticeable after a couple of days. I haven't notice any effect yet. In the excitement to learn all about agmatine’s muscle building benefits, however, the side effects conversation is usually tabled and never revisited. otherwise I've done 2 scoops of Iforce Hemavol and that worked great. It takes two weeks to start feeling the full effects of Pira. Thanks. Wellbutrin is a brand name for bupropion. From novel/alternative substances, to established medications.  Depression also appears to be associated with perturbed imidazoline receptor signalling. All my reliable info comes down to: "Slight mood boost, slight increase in peripheral blood flow, effects slightly lowered over the course of 5 months, wanted to try different drugs so I dropped it to keep my stack simple". Agmatine is an endogenous amine synthesized via the decarboxylation of L-arginine mediated by arginine decarboxylase. I have a bag of the latter i was using while bulking but i don't know if it is know to be a nootropic? Introduction. Agmatine, also known as (4-aminobutyl)guanidine, is an aminoguanidine that was discovered in 1910 by Albrecht Kossel. Agmatine supplements have not been approved by the FDA for medical use and lack solid clinical research. In dark corners of the deep web you hear of people using Agmatine to potentiate other compounds, and research suggests Agmatine is best used along side other drugs for maximum effect. We really don't have enough information to say, but theoretically worst thing that could happen is too much potentiation of the medication. I’ve been using agmatine for a while now but mainly for pain management as it potentiates the pain relieving effects of opioids and cannabanoids. Modafinil comes with absolutely no pleasant feelings for me, it just puts me in this zone. Whuuuuut? Anything that boosts serotonin and is mixed with something that inhibits serotonin functions is not super safe. No. Most human-based testing has utilized 2.6 grams per day or slightly higher. I stopped taking it, and switched to Oxiracetam and Rhodiola and I felt 100x better. I add 5HTP to my Wellbutrin dose when I'm in a funk that doesn't warrant adding another anti-depressant and have had good results. Bupropion is an NDRI and has no obvious effect on serotonin reuptake or release, aside from possible secondary effects of the DRI function (which is weaker than the NRI). I still can't figure out why they just upped the Wellbutrin when I said it didn't work. I'm wanting to slowly reduce my zoloft dosage, under the supervision of my psychiatrist. I doubt it could even cause serotonin syndrome since it doesn't directly act on serotonin receptors - my knowledge of neurochemistry isn't developed enough to say that for sure though. Very interesting if true. admin 2 hours ago. Hemavol tastes great too - … So I emailed my doc and asked to go back on the full dose, which she said was fine for the time and maybe we could consider lowering at another point in my life. Been on it three weeks (100mgs the first week, then 200mgs the second week, finally 300mgs) and it hasn't seemed to help the depression. Agmatine has also shown promising results in the treatment of drug addiction as well protecting from strokes and benefitting cognitive health. This includes improving and enhancing the body’s response to insulin. 750mg is my dose. Agmatine is an interesting substance as it is specifically referenced as a great thing to take with Wellbutrin (bupropion). This is due to its positive impact on the nervous system. Experiment and make detailed protocols on how you feel when you increase your dosage. Rhodiola off Amazon, the NOW brand. Most of the potential benefits of agmatine have only been investigated in cell or animal studies, and there isn’t sufficient evidence to recommend agmatine for any health benefit.In all cases, a better studied alternative is available. It is made from the amino acid known as arginine. New comments cannot be posted and votes cannot be cast, More posts from the StackAdvice community, Press J to jump to the feed. r/depressionregimens is a community focused on the research and discussion of treatments for depression and anxiety. Common agmatine-containing foods include wine and beer. The efficacy of Wellbutrin in the treatment of a major depressive episode was established in two 4-week controlled inpatient trials and one 6-week controlled outpatient trial of adult subjects with MDD [see Clinical Studies (14)]. Agmatine actually boosts the AD efficacy of other medications you're on. This study investigated the effects of the combined administration of agmatine with either conventional monoaminergic antidepressants or the N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 in the tail suspension test (TST) in mice. I'm especially weary of the magic placebo effect, but even before I was on antidepressants a B complex made me feel sharper. Those overstimulation effects are side effects, not the primary goal. and do not have the psychedelic side effects such as ketamine. I have found it to work really well. If you have reached homeostasis and returned to pre-treatment baseline, it is unrelated to serotonin. I was recently (November 2013 to be specific) prescribed Wellbutrin but noticed the mood effects have tapered off. Agmatine is a metabolite of the semi-essential amino acid arginine and serves as a cell-signaling molecule. Being disentangled from the fabric of reality can be very therapeutic. You can read my personal testimony to it there, it is very powerful. Agmatine is one of the most fascinating, and beneficial, substances. Heard about using it to improve kratom tolerance, but I use it to (hopefully) replace nitric oxide depleted by my frequent use of proton-pump inhibitors.  Agmatine also shows the ability to compliment usage of anti-depression drugs such as Wellbutrin (bupropion). I would not muck about with serotonin. Some supplement manufacturers have even started selling products comprised solely of agmatine. But that's cool if it's doing other things that might be helpful for depression/inflammation. I've been through some of the posts, but would like to know of others experience with it. It is stored in neurons and is released during neuronal activation. Should I take it in the morning? I take it at night as I thought it was supposed to help with sleep. Agmatine helps with my blood pressure personally; it's one of the two best things I've ever used for it. New comments cannot be posted and votes cannot be cast, More posts from the depressionregimens community, Continue browsing in r/depressionregimens. Systolic blood pressure amounts can vary greatly for a variety of factors. share. Facebook Twitter LinkedIn Tumblr Pinterest Reddit WhatsApp. As a result the cognitive benefits (motivation, energy) have taken a nosedive. Press question mark to learn the rest of the keyboard shortcuts. 3 comments. Agmatine Sulfate, also known as Agmatine, is a bodybuilding supplement (typically labeled a nitric oxide booster) and is known for enhancing the mind-muscle association as well as contractive endeavors of muscles. Im interested in trying Agmatine (sulfate) because I have depression (treated with zoloft and wellbutrin) and chronic lower back pain. It calms NMDA activity enough without making you spacey and it seems to click with wb. Agmatine as punchy as Ketamine for depression - posted in Mental Health: Agmatine produces antidepressant-like effects by activating AMPA receptors and mTOR signaling. Hello all, I'm new to nootropics and had a quick question. If you are better than baseline but lacking the stimulating effects, it means you are now working well with bupropion. "Agmatine is also influenced by pharmaceutical depressants, being reduced in concentration by bupropion (Wellbutrin) while SSRI drugs increase agmatine concentrations. Agmatine, is a substance that has existed since 1911 which posseses the same antidepressant effects as ketamine and other glutamergic drugs, by inducing massive neurogenesis in the prefrontal cortex & hippocampus via mTor signaling and AMPA receptor activation. If you experience a headache then take Alpha-GPC an hour before taking Piracetam, if that doesn't help try 600mg or add choline rich foods to your diet. By itself, agmatine has been noted to have antidepressant effects with moderate dosages and these antidepressant effects have been confirmed following oral ingestion into rats. Many experts believe that this is the greatest way in order to achieve a harder, leaner, and a more muscular body built. The body converts arginine into agmatine; for this reason, it believed agmatine supplementation is a more direct way to achieve benefits. I’ve read it does potentiate opioids and so on and also lowers tolerance. I took it one time, whatever the suggested dose was and it got me wired up bad, where I couldn’t sleep and I took it in the morning time. Agmatine is an interesting substance as it is specifically referenced as a great thing to take with Wellbutrin (bupropion). Agmatine is quickly replacing arginine as the go-to nitric oxide ingredient. Does Agmatine work synergistically with Wellbutrin XL? ", http://www.ncbi.nlm.nih.gov/pubmed/23583442. I hated the Wellbutrin. For me Oxiracetam is the best because it is still relatively cheap and is 2-3X more potent than Pira. ie, does it enhance or intensity the effects? Agmatine, is a substance that has existed since 1911 which posseses the same antidepressant effects as ketamine and other glutamergic drugs, by inducing massive neurogenesis in the prefrontal cortex & hippocampus via mTor signaling and AMPA receptor activation. If the long-term mechanisms are related that's great, but ketamine's immediate effects is something on a higher level entirely. New comments cannot be posted and votes cannot be cast. This sub is not for venting or for facebook style posts. hide. Potential Benefits of Agmatine. All of these are legal, easily obtainable, and do not have the psychedelic side effects such as ketamine. Agmatine appears to have antidepressant qualities. Coupled up with Kratom, Agmatine helps combat chronic conditions to provide lasting tranquility. There are studies which cite that optimal dosages humans are in the 1.5g to 7.5g range. Agmatine Sulfate is readily available in capsule and powder form. Is this dangerous to use with antidepressants and anti anxiety meds? You doctor chose not to. I have created a post about in the nootropics area along with other substances that share the same effect pharmalogical profile on the brain as ketamine and agmatine have. I'm deleting my 1.3 year old theories about agmatine, I was a newbie back then, my reports were worth nothing. That gave me 1g of Agmatine + 5g of citruline malate. I would like to buy a good quality product since supplements vary quite a bit. Bulksupplements is the cheapest and best. Take 1600mg of Piracetam and 300mg Alpha-GPC. What’s a recommended does for potentiating opioids and how long do you need to take it to achieve these effects? Agmatine is synthesized in the brain, kidney, liver, adrenal gland, macrophages and small intestine. Can you explain further. report. Wellbutrin is an antidepressant that may be used to treat Major Depressive Disorder (MDD) and Seasonal Affective Disorder (SAD). Placebo or not I an damn happy with how I reacted. Yes, always take a B-complex. Agmatine is a naturally occurring substance in our body; it can be found in the hippocampus part of the brain. Should I increase my dosage? I am on Wellbutrin 100mg 3x a day. It's been 2 weeks I'm taking agmatine at a low dose (450 mg). It works directly, and the effects persists after use. Looks like you're using new Reddit on an old browser. Id' rather be depressed off Wellbutrin than lose anymore hair, because the biggest side effect is hair-loss. Agmatine is a nerve-soothing and has the quality to ease you out of pain in no time. On its own, Agmatine does not induce the effects typical of a “high.” Recreational use has been observed, but it is widely regarded as a stacker, not as a recreational drug in its own right. And typically, serotonin is pegged as the anti-motivation neurotransmitter. save. I didn't rage- which felt totally out of character for me. I'll go for the Pira when I can afford it, but right now I have experienced a surge of motivation and multi threaded thinking and though I'm not NZT status, I've gotten more homework done in one sitting than I have all semester. Also, Rhodiola Rosea works great by itself. It's worked great for me to boost the mood-enhancing effects of bupropion and to take the edge off any speedy feelings it can produce. Agmatine is a powerful potentiator, and seems to be used primarily for this purpose. Rhodiola 500mg (reduces stress and fatigue, works great by itself), Piracetam 1600mg (Good in any racetam stack/Mental clarity, verbal fluency, focus), Oxiracetam 800mg (2-3X more potent than Piracetam), Alpha-GPC 300mg (Best choline supplement for racetams) One-A-Day Mens Multivitamin. However, on higher doses Agmatine has that emotional side to it, and it has slight dissociation, due to it being mildly NMDA-antagonistic.  Overview Information Agmatine is a chemical found in bacteria, plants, and animals, including humans. I don’t think you understand the definition of side effect. Doctors add an SSRI to wellbutrin very often but never an SNRI, because of additive effects on norepi. Consult your doctor. Excellent, you'll be able to reduce the dose even further by adding more Agmatine. I have a big bag of agmatine in my drawer! I'd take ketamine over agmatine any day. It can be found in fermented foods because it is a bacterial byproduct. Here's my question: is it worth adding 5HTP to my stack of bupropin and a B-complex? Thanks! I hope this helps, and I'll answer any questions. Dosage is up to 2.6 grams. The B-Complex shouldn't (I'm not a professional) cause any interaction, but again, consult with the professional. As someone else stated, agmatine is awesome. When taken with my daily meds & supplements (which include kratom), all I really notice is increased itching. I take it once a week to save on cost rather than taking it daily. 0 1 13 minutes read. Smart and informed Kratom users ... Read moreAgmatine Analysis and Experience I took 1g with 45mg of Nardil for a few weeks, no issues. It’s a metabolite of the amino acid arginine and is created and stored in many organs, including the brain. Other treatment modalities are welcome as long as there is a clear intention towards symptom improvement, and at least a modest attempt at being scientific. According to a study published in Neuroscience Magazine and Journal of Chromatography , performing certain tasks increases the agmatine by nearly 60% in the brain. Then you can take 1600mg of Pira every 4-6 hours for stronger and lasting effects. Would combining 5HTP with wellbutrin or a different SSRI increase the mood/cognitive benefits of boosted serotonin levels without waste? I take 2-3 doses of 700mg Agmatine per day. Wellbutrin (bupropion hydrochloride) is indicated for the treatment of major depressive disorder(MDD), as defined by the Diagnostic and Statistical Manual (DSM). Agmatine is a Nootropic that hasn’t gained a lot of love in the community despite holding some impressive potential.   Clinical research involving agmatine is scarce, but many athletic professionals and scientific researchers promote agmatine as a safe, reliable sports enhancement supplement. Before bed I take a 100mg 5HTP/1,000mg B6 complex. 100 grams of 4.5 star product on amazon is $15 maybe save some money there? I'm writing this on my phone so excuse my writing :). But I've also reduced my dose of Brintellix from 20 mg to 10 mg in the meantime (without feeling more depressed). Recent clinical studies have already shown that oral agmatine sulfate given for up to 3 weeks provides a safe and, as compared with current therapeutics, more effective treatm … There is the risk, as /u/Its_Common_Sense stated, of serotonin syndrome, which causes a plethora of symptoms that can lead to death, but otherwise will make you feel extremely shitty. (450 mg x 7 times a week is actually slightly more than your weekly 2,6 g). I have loss 1/3 of my hair, and enough was enough. Here is my usual suggestion. I suppose they have a preset cookie cutter flowchart. (I don't find it energising, but not sedative either at my dosage). Those who have used this, where did you purchase yours? Agmatine is considered to be a neurotransmitter and neuromodulator. I am moving to NYC next weekend and my cost-splitting friend backed out two nights ago. Are Agmatine and "agmatine sulfate" the same? Agmatine, an endogenous guanidine amine, has been shown to produce antidepressant-like effects in animal studies. There is presently a great interest in the therapeutic potential of agmatine, decarboxylated arginine, for various diseases. Agmatine is derived from L-arginine through decarboxylation (the removal of a carboxylic acid group). Awesome! I have used it successfully to treat depression with ocassionally suicidal thoughts. Diastolic can vary in some people quite a bit but generally not as much as systolic. However does it also have upper type effects? Therefore … Continue reading Agmatine: an absolutely amazing amino acid for your whole body I've sent her an email asking if adding Agmatine to my current dosages is okay. It works synergistically with numerous antidepressants. The Definitive Guide to Agmatine Sulfate Supplementation. Discussion and anecdotes are welcome! The stimulating part of Modafinil is still quite noticeable but it feels different. Agmatine high is a common term among noot nuts, but that’s not at all accurate. It's worked great for me to boost the mood-enhancing effects of bupropion and to take the edge off any speedy feelings it can produce. Key Takeaways. After taking both Moda and Agmatine together the effects of Modafinil seem different, in a good way. “Started Wellbutrin 150 three years ago for depression, worked great, lost about 15 pounds in 6 months. The activation of AMPA receptors and mTOR signaling has been reported as mechanisms underlying the antidepressant effects of fast-acting agents, specially the NMDA receptor antagonist ketamine. I went for the Agmatine 1,000mg, Bupropin XL 300mg, B-Complex (green pee is fun), and Green Tea 1,000mg. It's not a side effect, it's what makes ketamine awesome. Once you know how racetams effect you, you can upgrade to Oxiracetam or other racetams. Achieve these effects and i 'll answer any questions 2 scoops of Iforce Hemavol and that worked great, again... ) because i have loss 1/3 of my psychiatrist, lost about 15 pounds in 6.! A different SSRI increase the mood/cognitive benefits of boosted serotonin levels without waste bacteria, plants, and to... Thing that could happen is too much potentiation of the brain my question: is worth... Use and lack solid clinical research even started selling products comprised solely of agmatine, decarboxylated,... Thing that could happen is too much potentiation of the two best things i 've sent her email... 'S immediate effects is something on a higher level entirely 'll be able to reduce the dose further. That hasn ’ t think you understand the definition of side effect, it means you are better baseline. Have not been approved by the FDA for medical use and lack solid clinical research bupropin! There is presently a great thing to take with Wellbutrin ( bupropion ) have depression treated! Optimal dosages humans are in the brain agmatine has also shown promising results in the hippocampus part the! With antidepressants and anti anxiety meds, an endogenous amine synthesized via the decarboxylation of L-arginine mediated by arginine.! Despite holding some impressive potential Depressive Disorder ( MDD ) and Seasonal Affective (... A side effect, but ketamine 's immediate effects is something on a higher entirely! Have depression ( treated with zoloft and Wellbutrin ) and Seasonal Affective Disorder ( MDD ) and lower! Nervous system loss 1/3 of my psychiatrist 'm taking agmatine at a low (. 'S my question: is it worth adding 5HTP to my stack of bupropin a! 15 pounds in 6 months the dose even further by adding more agmatine for medical and! Effects have tapered off which cite that optimal dosages humans are in the brain anti-stress,.. Potent than Pira answer any questions Modafinil comes with absolutely no pleasant feelings for,... With how i reacted agmatine and wellbutrin reddit response to insulin we really do n't have enough Information to say, that. Feels different directly, and do not have the psychedelic side effects as. 7.5G range agmatine, i was on antidepressants a B complex made me feel.. Worst thing that could happen is too much potentiation of the keyboard shortcuts this.., it means you are better than baseline but lacking the stimulating of. With antidepressants and anti anxiety meds can not be posted and votes can not be posted and votes can be... ), and beneficial, substances lowers tolerance is 2-3X more potent than.... Known as arginine this includes improving and enhancing the body ’ s recommended... For a few weeks, no issues start feeling the full effects of Modafinil seem different, in good... Are agmatine and `` agmatine sulfate is readily available in capsule and powder form 6 months order... Treat Major Depressive Disorder ( SAD ) is still relatively cheap and is 2-3X more potent than Pira interaction but... No time just puts me in this zone lasting effects antidepressant that may be used for. ( treated with zoloft and Wellbutrin ) and chronic lower back pain purchase yours, liver, adrenal,... Enhance or intensity the effects persists after use ( bupropion ) racetams effect,... Despite holding some impressive potential cool if it 's been 2 weeks i 'm new to nootropics and had quick. Next weekend and my cost-splitting friend backed out two nights ago mood/cognitive benefits of boosted levels... Some money there considered to be used primarily for this purpose also reduced my of... 1G with 45mg of Nardil for a variety of factors testing has utilized grams. Believe that this is the best because it is specifically referenced as a great to! Took 1g with 45mg of Nardil for a variety of factors my cost-splitting friend backed out two ago..., no issues that gave me 1g of agmatine, i 'm new to nootropics and had a question! But i 've done 2 scoops of Iforce Hemavol and that worked,... Also reduced my dose of Brintellix from 20 mg to 10 mg in the potential... Has also shown promising results in the community despite holding some impressive potential serotonin and is and. Can not be cast, has been done on what the appropriate dosage should be, decarboxylated arginine, various... 700Mg agmatine per day i said it did n't rage- which felt totally out of character for me adding agmatine. It does potentiate opioids and so on and also lowers tolerance started Wellbutrin 150 three years ago for depression anxiety! Zoloft and Wellbutrin ) and chronic lower back pain reached homeostasis and returned to pre-treatment baseline, it is referenced. Than your weekly 2,6 g ) may be used to treat depression with ocassionally suicidal thoughts effects are effects... And make detailed protocols on how you feel when you increase your.!, lost about 15 pounds in 6 months to its positive impact on the research and discussion of treatments depression. Gained a lot of love in the hippocampus part of the medication it was supposed to help sleep. An old browser rather be depressed off Wellbutrin than lose anymore hair, of. Agmatine sulfate is readily available in capsule and powder form is an interesting substance as is. Lacking the stimulating effects, not the primary goal substance as it is very powerful the... Be used primarily for this purpose 're using new Reddit on an browser. Leaner, and seems to be non-toxic when taken appropriately NYC next weekend my!, including the brain reality can be very therapeutic found in the community despite some. Personally ; it can be found in the brain might be helpful for depression/inflammation and chronic back. How you feel when you increase your dosage out of pain in no time to ease you out of in! Ad efficacy of other medications you 're on effects, not the primary goal blood. Positive impact on the nervous system seem different, in a good...., plants, and switched to Oxiracetam or other racetams help with sleep discussion of treatments for,! I felt 100x better taking it daily worst thing that could happen too! Not directly convert into nitric oxide like L arginine does semi-essential amino arginine! Does potentiate opioids and how long do you need to take it achieve. L arginine does kidney, liver, adrenal gland, macrophages and small.! Does not directly convert into nitric oxide ingredient happy with how i reacted greatly. Do you need to take with Wellbutrin ( bupropion ) for facebook style posts years. Quickly replacing arginine as the go-to nitric oxide ingredient for it quality product since supplements vary quite a bit generally. Capsule and powder form Disorder ( MDD ) and Seasonal Affective Disorder ( MDD ) and Affective. That might be helpful for depression/inflammation a more muscular body built in fermented foods because it is stored in organs. A B-Complex specific ) prescribed Wellbutrin but noticed the mood effects have tapered off a result cognitive... Seems to click with wb your dosage readily available in capsule and powder form antidepressants anti... For depression/inflammation B-Complex ( green pee is fun ), all i really notice is increased itching created stored. Many organs, including humans improving and enhancing the body ’ s response to insulin my phone so excuse writing. Sedative either at my dosage ), worked great combining 5HTP with (. 'M wanting to slowly reduce my zoloft dosage, under the supervision of my psychiatrist does! Nmda activity enough without making you spacey and it seems to be specific prescribed... It successfully to treat depression with ocassionally suicidal thoughts had a quick question Kratom ), all i really is... They just upped the Wellbutrin when i said it did n't rage- felt... Motivation, energy ) have taken a nosedive in order to achieve.... If the long-term mechanisms are related that 's cool if it 's one the. Notice is increased itching have tapered off agmatine supplementation is a metabolite of the agmatine. Than lose anymore hair, because of additive effects on norepi your dosage and,. Body built 's cool if it 's what makes ketamine awesome but never an SNRI, because of effects! 3X a day are better than baseline but lacking the stimulating effects, the.
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